ALYREF Antibody Blocking Peptide

基本信息: 中文名称: ActivAbTMALYREF 抗体封闭肽 英文名称: ActivAbTMALYREF Antibody Blocking Peptide 别名: ALY,ALY/REF,BEF,REF,THOC4,THO complex subunit 4 外观(性状): Lyophilized powder 来源: Synthetic 储存条件: Store at -20°C. Avoid freeze / thaw cycles. 运输条件: 冷冻运输 规格: 500ug 生物活性: 应用: Blocking Peptide of K107490P Antibody 纯化方法: HPLC 背景说明: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-in...

英文名:ActivAbTMALYREF Antibody Blocking Peptide 别名:ALY,ALY/REF,BEF,REF,THOC4,THO complex subunit 4 品牌:UGUIGIO

CAS号:N/A 分子式:N/A 分子量:N/A

所属类目:其他多肽 危险性质:N/A

货号 规格 华南仓 华东仓 纯度 目录价 促销价 数量
9107490K-Ag-500ug 500ug 3-5天 1-3天 N/A ¥648 ¥486
分享

相关产品

NOCT Antibody Blocking Peptide(2)
NOCT Antibody Blocking Peptide(2)

英文名:NOCT Antibody Blocking Peptide 别名:CCR4 carbon catabolite repression 4 like (S. cerevisiae); CCR4 protein homolog; CCRN4L; NOC 品牌:UGUIGIO

CAS号:N/A 分子式:N/A 分子量:N/A 所属类目:其他多肽 危险性质:N/A

货号 规格 华南仓 华东仓 纯度 目录价 促销价 数量
9118455K-Ag-500ug 500ug 3-5天 1-3天 N/A ¥648 ¥486
NOCT Antibody Blocking Peptide(1)
NOCT Antibody Blocking Peptide(1)

英文名:NOCT Antibody Blocking Peptide 别名:CCR4 carbon catabolite repression 4 like (S. cerevisiae); CCR4 protein homolog; CCRN4L; NOC 品牌:UGUIGIO

CAS号:N/A 分子式:N/A 分子量:N/A 所属类目:其他多肽 危险性质:N/A

货号 规格 华南仓 华东仓 纯度 目录价 促销价 数量
9118454K-Ag-500ug 500ug 3-5天 1-3天 N/A ¥648 ¥486
MMAA Antibody Blocking Peptide(2)
MMAA Antibody Blocking Peptide(2)

英文名:MMAA Antibody Blocking Peptide 别名:mitochondrial; cblA; MMAA protein; Methylmalonic aciduria (cobalamin deficiency) cblA type; Methylmalonic aciduria (cobalamin deficiency) type A; 品牌:UGUIGIO

CAS号:N/A 分子式:N/A 分子量:N/A 所属类目:其他多肽 危险性质:N/A

货号 规格 华南仓 华东仓 纯度 目录价 促销价 数量
9118447K-Ag-500ug 500ug 3-5天 1-3天 N/A ¥648 ¥486
MMAA Antibody Blocking Peptide(1)
MMAA Antibody Blocking Peptide(1)

英文名:MMAA Antibody Blocking Peptide 别名:mitochondrial; cblA; MMAA protein; Methylmalonic aciduria (cobalamin deficiency) cblA type; Methylmalonic aciduria (cobalamin deficiency) type A; 品牌:UGUIGIO

CAS号:N/A 分子式:N/A 分子量:N/A 所属类目:其他多肽 危险性质:N/A

货号 规格 华南仓 华东仓 纯度 目录价 促销价 数量
9118446K-Ag-500ug 500ug 3-5天 1-3天 N/A ¥648 ¥486
 
 
基本信息:

中文名称:

ActivAbTMALYREF 抗体封闭肽

英文名称:

ActivAbTMALYREF Antibody Blocking Peptide

别名:

ALY,ALY/REF,BEF,REF,THOC4,THO complex subunit 4

外观(性状):

Lyophilized powder

来源:

Synthetic

储存条件:

Store at -20°C. Avoid freeze / thaw cycles.

运输条件:

冷冻运输

规格:

500ug



生物活性:

应用:

Blocking Peptide of K107490P Antibody

纯化方法:

HPLC

背景说明:

Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.

生物活性:

Not tested
该产品为 ALYREF 抗体的抗原肽,在抗体检测、纯化时作为封闭肽使用,对应抗体货号为:K107490P。
抗体封闭肽是一类专门用于免疫学检测体系的功能性合成多肽,其核心作用是通过特异性结合干扰性抗体或非特异性结合位点,从而降低实验背景信号,提高检测结果的准确性和可靠性。它并不直接识别目标抗原,而是充当一种“分子屏蔽层”,封闭那些可能导致假阳性或假阴性结果的非特异性相互作用。
在功能层面,抗体封闭肽主要具备两大特性。一是高亲和力的特异性中和能力——其氨基酸序列与检测体系中可能引起交叉反应的抗体表位完全相同或高度同源,因此能够优先与这些干扰抗体结合,占据其活性位点。二是物理屏蔽作用,即在不干扰靶标抗原与检测抗体正常识别的前提下,封闭固相载体或捕获分子上的空缺结合区域,减少杂蛋白或杂抗体的非特异性吸附。
在应用层面,抗体封闭肽广泛应用于各类免疫分析技术中,包括酶联免疫吸附测定、蛋白质印迹、免疫组化以及免疫层析试纸条等。在自身抗体检测、生物制剂的免疫原性分析以及多重免疫检测方法开发中,它能够有效消除由异嗜性抗体、抗物种抗体或样本基质效应引起的背景干扰。此外,在基于标签融合蛋白的表达检测以及抗体亲和纯化流程中,封闭肽同样扮演着关键角色,可作为竞争性洗脱剂或信号校正控制组使用。
注意事项:
1.本产品仅供科研使用,请勿用于医药、临床治疗、食品及化收品等用途 。
2.为了您的安全和健康,请穿实验服,口罩,护目镜,并戴一次性手套操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。
4.请勿存放于普通住宅区。
N/A
  • toolbar
    toolbar
  • toolbar