α-Synuclein (34-45) (human)

基本信息: 中文名称: α-突触核蛋白(34-45) 英文名称: α-Synuclein (34-45) (human) CAS: 2170181-52-7 分子式: C59H101N15O18 分子量: 1308.54 纯度: ≥95% 别名: alpha-Synuclein (34-45) (human) 外观(性状): 冻干粉;Lyophilized powder 来源: 合成;Synthetic 储存条件: Store at -20℃,2 years.(Avoid freeze/thaw cycles) 运输条件: 冷冻运输 规格: 1mg ; 5mg ; 10mg 生物活性: 背景说明: The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif w...

英文名:α-Synuclein (34-45) (human) 别名:alpha-Synuclein (34-45) (human) 品牌:UGUIGIO

CAS号:2170181-52-7 分子式:C₅₉H₁₀₁N₁₅O₁₈ 分子量:1308.54

所属类目:神经肽及相关肽 危险性质:N/A

货号 规格 纯度 华南仓 华东仓 目录价 促销价 数量
90222-1mg 1mg ≥95% 3-5天 1-3天 ¥648 ¥486
90222-5mg 5mg ≥95% 3-5天 1-3天 ¥1620 ¥1215
90222-10mg 10mg ≥95% 3-5天 1-3天 ¥2268 ¥1701
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基本信息:

中文名称:

α-突触核蛋白(34-45)

英文名称:

α-Synuclein (34-45) (human)

CAS:

2170181-52-7

分子式:

C59H101N15O18

分子量:

1308.54

纯度:

≥95%

别名:

alpha-Synuclein (34-45) (human)

外观(性状):

冻干粉;Lyophilized powder

来源:

合成;Synthetic

储存条件:

Store at -20℃,2 years.(Avoid freeze/thaw cycles)

运输条件:

冷冻运输

规格:

1mg ; 5mg ; 10mg



生物活性:

背景说明:

The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
α-Synuclein (34-45) (human) 是一种人工合成的多肽,序列为:Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys(单字母序列为:KEGVLYVGSKTK),分子式为:C59H101N15O18,理论分子量为:1308.54Da。
The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
多肽是由两个或多个氨基酸通过肽键连接形成的一类化合物,介于氨基酸与蛋白质之间,是生命活动的核心执行分子之一,其结构可根据氨基酸序列精准调控,适配不同场景的功能需求。
多肽的核心功能围绕生理调节、免疫防御、营养补给与组织修复四大维度展开,每一种多肽的氨基酸序列都决定了其独特的功能特性。在生理调节方面,多肽可作为信号分子参与神经、内分泌、代谢等系统的调控,免疫防御层面,免疫活性肽能刺激淋巴细胞、巨噬细胞增殖,增强机体对病原微生物的抵抗力,抗菌肽可破坏细菌细胞膜,实现广谱抗菌且不易产生耐药性,为机体构建天然防护屏障。同时,多肽还具备优异的抗氧化能力,可清除体内多余自由基,减轻氧化应激对细胞的损伤,延缓衰老进程。
拥有经验丰富的多肽研究团队,以及世界尖端水平的TETRAS自动化多肽合成仪、高效液相色谱仪、液质联用仪等专业设备,确保了研发、生产流程以及产品质量的可靠性严格控制生产流程。的多肽研发部门可根据不同应用场景提供目录化产品和定制化解决方案,满足科学研究的多层次、多用途和多样化需求。
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